Bioresorbable sealants for porous vascular grafts
AssigneeMeadox Medicals, Inc.
InventorsDavid J. Lentz, Gary L. Loomis, Antonio Moroni, Jennifer DePreker
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Abstract
A bioresorbable sealant composition useful for impregnating implantable soft-tissue prostheses includes at least two polysaccharides in combination to form a hydrogel or sol-gel. The sealant compositions may optionally include a bioactive agent and/or be cross-linked subsequent to application of these compositions to the substrate surface.
Claims19
An implantable liquid-tight tubular prosthesis comprising:
- inner and outer porous walls, said walls having a porosity which is conducive to tissue ingrowth, said walls further being impregnated with a hydrogel comprising in combination at least two polysaccharides which interact to form a stable bioresorbable liquid tight sealant throughout said tubular prosthesis.
A controlled-release bioresorbable sealant composition for use in soft tissue prostheses comprising:
- a hydrogel matrix,
- a bio-active agent incorporated therein, said hydrogel comprising in combination at least two polysaccharides which when combined in an aqueous medium interact to form said hydrogel and which when impregnated into a porous soft-tissue prosthesis provides a liquid-tight seal.
An implantable soft tissue prosthesis which comprises:
- a tubular member having inner and outer porous walls for tissue ingrowth, said prosthesis impregnated with a bioresorbable hydrogel sealant, said bioresorbable hydrogel sealant including in combination a seed gum polysaccharide and a sea weed extract polysaccharide dispersed in a glycerol-water solution.
A method for rendering an implantable soft tissue porous substrate fluid-tight comprising:
- a. providing said implantable soft tissue porous substrate having inner and outer surfaces and a porosity defined by pores in said surfaces;
- b. impregnating said surfaces with a hydrogel defined by at least two polysaccharides to fill said pores with said hydrogel;
- c. allowing said hydrogel to form a seal in said pores rendering said substrate liquid-tight.
A method for rendering an implantable soft tissue porous substrate fluid-tight comprising:
- a. providing said implantable soft tissue porous substrate having inner and outer surfaces and a porosity defined by pores in said surfaces;
- b. impregnating said surfaces with a sol-gel defined by at least two polysaccharides to fill said pores with said sol-gel;
- c. allowing said sol-gel to form a seal in said pores rendering said substrate liquid-tight.
An implantable soft tissue prosthesis that comprises:
- a tubular member having inner and outer porous walls for tissue ingrowth, said member impregnated with a bioresorbable hydrogel sealant, said bioresorbable hydrogel sealant comprising in combination a linear polysaccharide component and a branched polysaccharide component dispersed in a glycerol-water solution.
Dependencies are inferred from the claim text.