US 5,849,998 AGranted

Transgenic animals expressing a multidrug resistance cDNA

AssigneeUnited States of America

InventorsMichael M. Gottesman, Ira Pastan, Kazumitsu Ueda, Hanan Galski, Glenn Merlino

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Abstract

The present invention provides for vectors carrying a cDNA containing the entire coding region of the human multidrug resistance gene (MDR1) and for a method for introducing MDR1 cDNA into cells thereby inducing a multidrug resistant phenotype.

Claims11

Dependent claims

A non-human transgenic mouse having cells that carry and express a human MDR1 cDNA wherein said cells constituitively express a multidrug resistant phenotype.

Dependencies are inferred from the claim text.

Facts

Application: 08/481,730Filed 7 Jun 1995 · continuation
Priority: 16 Jun 1987
Granted: 15 Dec 1998
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

A01K 67/0271
New or modified breeds of vertebrates: chimeric vertebrates, e.g. comprising exogenous cells
C07K 14/705
From animals; from humans: receptors; Cell surface antigens; Cell surface determinants
A01K 2217/05
Genetically modified animals: animals comprising random inserted nucleic acids
C12N 2799/027
For the expression of a heterologous nucleic acid: where the vector is derived from a retrovirus

Family

Serial62,583Parent of this continuation-in-part · filed 16 Jun 1987
Serial202,782Parent of this continuation-in-part · filed 3 Jun 1988
Serial701,576Parent of this continuation-in-part · filed 14 May 1991
Serial416,623Parent of this continuation · filed 4 Apr 1995
Serial62,583Parent of this continuation
US 5,849,998 AThis patent

From the US filing history. Foreign family members aren’t listed.

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