Transgenic mice as a model for metabolic bone diseases
AssigneeHoechst Japan Limited
InventorsNorihiro Tada, Masahiro Sato, Takashi Kobayashi, Toru Ikeda, Katsuiku Hirokawa
Life of this patent
Estimating the term…
Abstract
Transgenic mice carrying a recombinant DNA construct comprising the gene encoding diphtheria toxin A chain operably linked to a osteocalcin promoter. The transgenic mice can be used as a model for metabolic bone diseases since they have decreased bone mass associated with a marked reduction in the number of osteoblasts.
Claims2
A transgenic mouse displaying phenotypic characteristics indicative of metabolic bone disease, wherein said mouse lacks functional osteoblasts, wherein the genome of said mouse comprises a recombinant DNA construct consisting of the gene encoding diphtheria toxin A chain operably linked to a rat osteocalcin promoter, and wherein expression of said diphtheria toxin A chain in the osteoblasts of said mouse results in the genetic ablation of said osteoblasts in said mouse.
Dependencies are inferred from the claim text.