Rat comprising straight filaments in its brain
AssigneeThe Trustees of the University of Pennsylvania
InventorsJohn Q. Trojanowski, Virginia M.-Y. Lee, Ryong-Woon Shin
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Abstract
Methods of generating a rat having A.beta. deposits in the brain of the rat by injecting an amount of human A68 protein sufficient to result in formation of the deposits and subsequently examining the rat for the formation of the deposits are disclosed. Rats characterized by the presence of A.beta. deposits similar to those found in individuals with Alzheimer's disease are also disclosed. Methods of screening test compositions for prophylactic or therapeutic activity by generating a rat having A.beta. deposits in its brain, treating the animal with the test composition and examining the animal for therapeutic or prophylactic effectiveness are also disclosed.
Claims28
A rat comprising straight filaments in its brain, wherein the rat is produced by injecting a sufficient amount of A68 protein to induce formation of said straight filaments.
A method of generating a rat comprising straight filaments in its brain comprising injecting into said rat's brain an amount of purified human A68 protein sufficient to induce the formation of said straight filaments.
A method of identifying compositions which inhibit the formation of straight filaments in the brain comprising,
- a) administering a test composition to a rat, wherein the rat which has had injected into its brain a sufficient amount of purified human A68 protein to cause the formation of said straight filaments, and wherein the compound is administered to said rat prior to the formation said straight filaments;
- b) comparing the brain of the rat in step a) with the brain of a rat which has had injected into its brain a sufficient amount of purified human A68 protein to cause the formation of said straight filaments, and wherein said rat did not receive the test composition;
- and
- c) evaluating said rats for the prophylactic effect of said test composition on the formation of said straight filaments.
A composition comprising human A68, or salt thereof, aluminum, and a liquid vehicle suitable for injection.
Dependencies are inferred from the claim text.