Animal model for hepatitis virus infection
AssigneeYeda Research and Development Co. Ltd.
InventorYair Reisner
Life of this patent
Estimating the term…
Abstract
Chimeric mouse and rat models useful as models for human hepatitis virus (HV) infection are disclosed. These chimeras are made by substantially destroying the hematopoietic cells of a host mouse or rat and then transplanting into the resultant animal hematopoietic cells from SCID mice. The resultant chimera is then used as a host for transplantation of xenogeneic liver tissue, including liver tissue from humans. The liver tissue may be infected with HV either prior to or after transplantation.
Claims12
A chimeric mouse or rat having a stable transplant of xenogeneic liver tissue, useful as a model for human hepatitis virus (HV) infection, comprising a mouse or rat M5 having xenogeneic cells;
- said mouse or rat M5 being a mouse or rat M1, the hematopoietic cells of which have been substantially destroyed, and then transplanted with hematopoietic cells from one or more SCID mice M2 and transplanted with liver tissue from a xenogeneic mammal M3 of a species that can be infected by HV;
- said xenogeneic liver tissue in said mouse or rat M5 being infected by HV.
A chimeric mouse or rat having a stable transplant of xenogineic liver tissue, useful as a model for the evaluation of the efficacy of anti-HV prophylactic treatment, comprising a mouse or rat M4, being a mouse or rat M1, the hematopoietic cells of which have been substantially destroyed, and then transplanted with hematopoietic cells from one or more SCID mice M2 and transplanted with non-HV infected adult liver tissue from a xenogeneic mammal M3 of a species capable of being infected by HV.
Dependencies are inferred from the claim text.