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US 5,849,954 AGranted
Method of peptide synthesis
AssigneeResearch Corporation Technologies, Inc.
InventorsLouis A. Carpino, Dumitru Ionesou
Life of this patent
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Abstract
The present invention relates to a process for forming an N-.alpha.-amino protected amino acid fluoride in situ by reacting an N-.alpha.-amino protected amino acid with an ionic fluoride salt in the presence of a peptide coupling agent. It is also directed to the use of the amino acid fluoride thus formed in peptide synthesis.
Claims6
A compound of the formula:
- PQ.sub.5 Q.sub.6 Q.sub.7 Q.sub.8 (Ani)
- wherein
- Ani is Ly (HF).sub.z F.sup..crclbar. or TG.sub.1 G.sub.2 G.sub.3 F.sub.2.sup..crclbar. ;
- z is 0-10;
- y is 1;
- L is TG.sub.1 G.sub.2 G.sub.3 G.sub.4 ;
- T is a Group IV element consisting of Si, Ge, Sn and Pb;
- G.sub.1, G.sub.2, G.sub.3 and G.sub.4 are independently halogen, hydrogen, alkyl, aryl, aryl alkyl, cycloalkyl or cycloalkyl alkyl;
- Q.sub.5 is aryl alkyl;
- and
- Q.sub.6, Q.sub.7 and Q.sub.8 are independently aryl;
- wherein
- alkyl contains 1-20 carbon atoms;
- aryl is an aromatic ring containing 6 to 10 ring carbon atoms and up to a total of 15 carbon atoms;
- and
- cycloalkyl contains only ring carbon atoms and from 3-10 ring carbon atoms and up to a total of 15 carbon atoms.
13 more elements
Dependencies are inferred from the claim text.