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US 5,849,936 AGranted
Method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins
AssigneeRegents of the Univeristy of Minnesota
InventorsThomas R. Hoye, Lushi Tan
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Abstract
A method for the synthesis of bis-tetrahydrofranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.
Claims4
A compound of formula:
- ##STR56## wherein R.sup.3 is alkyl or aryl, R.sup.4 is H or a removable hydroxyl protecting group and R.sup.2 is alkyl or aryl.
Dependencies are inferred from the claim text.