Process for separating carbinols
AssigneeLaboratorios Del Dr. Esteve, S.A.
InventorsJordi Frigola-Constansa, Juana Maria Berrocal Romero, Maria Rosa Cuberes Altisent, Vicente Gotor Santamaria
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Abstract
A method for predominantly preparing the enantiomer (R)-(+)-5-(phenyl)hydroxymethyl-1-methyl-1H-pyrazole, (R)-(+)-1, by separating the racemate (+)-5-(phenyl)hydroxymethyl-1-methyl-1H-pyrazole of formula (1), comprising the series of steps of using a lipase or material derived therefrom having enzymatic activity in a transesterification reaction, as well as hydrolysing the resulting ester, (S)-(-)-5-(phenyl)alkylcarbonyloxymethyl-1-methyl-1H-pyrazole, of formula (S)-(-)-4, wherein R.sub.1 is a methyl or ethyl radical.
Claims8
Process for preparing preponderantly the enantiomer (R)-(+)-5-(phenyl)hydroxymethyl-1H-pyrazole, (R)-(+)-1, by separation of the racemic mixture (.+-.)-5-(phenyl)hydroxymethyl-1-methyl-1H-pyrazole, of formula 1, which comprises reacting a lipase in a transesterification reaction, followed by the hydrolysis of the ester formed, (S)-(-)-5-(phenyl)alkylcarbonyloxymethyl-1 methyl-1H-pyrazole, of formula (S)-(-)-4 in which R.sub.1 represents a methyl or ethyl radical ##STR3##
Dependencies are inferred from the claim text.