Pyrazolidine derivative radical scavenger brain-infarction depressant and brain-edema depressant
AssigneeShiseido Company, Ltd.
InventorsChikao Nishino, Tatsuya Otake, Kentaro Adachi, Ryuhei Inada
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Abstract
A pyrazolidine derivative or a salt thereof in accordance with the present invention is expressed by the following formula 1: ##STR1## wherein A represents a group expressed by --CH.sub.2 --, --CO--, --CS--, --CH.sub.2 CO--, or --CH.dbd.CH--CO--; B represents a group expressed by --O-- or --NH--; n is an integer of 1 or 2; R represents an alkenyl group; and R.sub.1 and R.sub.2 represent a lower alkyl or benzyl group. The pyrazolidine derivative above mentioned, as a radical scavenger, has antioxidant effect and lipid peroxidation inhibitory activity so as to be available for inhibiting brain infarction or brain edema.
Claims17
A pyrazolidine derivative or a salt thereof expressed by the following formula 1:
- ##STR9## wherein A represents a group expressed by --CH.sub.2 --, --CO--, --CS--, --CH.sub.2 CO--, or --CH.dbd.CH--CO--;
- B represents a group expressed by --O-- or --NH--;
- n is an integer of 1 or 2;
- R represents an alkenyl group;
- and R.sub.1, and R.sub.2 represent a lower alkyl or benzyl group.
Dependencies are inferred from the claim text.