Fused benzeneoxyacetic acid derivatives which have PGI.sub.2 receptor anonist activity

A fused benzeneoxyacetic acid derivative of the formula (1):

• ##STR153## R.sup.1 is (i) hydroxy,
• (ii) C.sub.1-12 alkoxy or
• (iii) NR.sup.2 R.sup.3 ;
• R.sup.2 and R.sup.3 each, independently, is
• (i) hydrogen atom or
• (ii) C.sub.1-4 alkyl;
• or
• together with the nitrogen form a naturally occurring amino acid;
• R.sup.4 each, independently, is
• (i) hydrogen atom,
• (ii) C.sub.1-4 alkyl,
• (iii) phenyl or
• (iv) C.sub.1-4 alkyl substituted by one or two rings optionally selected from a 6 membered monocyclic hetero ring containing one nitrogen atom or phenyl;
• the said phenyl and hetero rings may also be substituted by one to three of C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen atom, nitro or trihalomethyl when R.sup.4 is phenyl or the group containing phenyl or a 6 membered monocyclic hetero ring containing one nitrogen atom;
• Y is oxygen atom or sulfur atom;
• e is 3-5;
• f is 1-3;
• l is 1-3;
• p is 1-4;
• q is 0-2;
• r is 1-4;
• s is 0-3;
• with the proviso that;
• (1) when A is ##STR154## wherein all the symbols are the same meaning hereinbefore defined, q or s in not zero;
• (2) when A is ##STR155## wherein Y and l have the same meaning as hereinbefore defined, and R.sup.4 is C.sub.1-4 alkyl substituted by a hetero ring, a hetero ring in R.sup.4 should be bonded to the alkyl via a carbon atom in the hetero ring;
• and
• (3) --(CH.sub.2).sub.r -- or .dbd.CH--(CH.sub.2).sub.s -- should be bonded to the carbon atom at the a or b position in the D ring;
• or non-toxic salts thereof or non-toxic acid addition salts thereof.