Amino acid derivatives, processes for the manufacture thereof and pharmaceutical compositions containing these compounds

A compound of formula I ##STR359## wherein R.sup.1 is ##STR360## A.sup.1 is D- or L-proline or D- or L-hydroxyproline B is R.sup.5 wherein

• R.sup.5 is an amine of formula II or formula III ##STR361## wherein R.sup.6 is aralkyl, diarylalkyl (in these groups aryl is phenyl or naphthyl and alkyl (C.sub.1-5)alkyl), heteroaryl-(C.sub.1-5)alkyl (wherein heteroaryl is 2-, 3- or 4-pyridyl or 2- or 3-thienyl), phenylamino-(C.sub.1-5)alkyl, naphthylamino-(C.sub.1-5)alkyl or N-phenylalkylpiperidinyl (wherein the phenyl groups listed are not substituted or contain 1, 2 or 3 substituents which are, independently of each other (C.sub.1-5)alkyl, (C.sub.1-5)alkoxy, dimethylamine, halogen, trifluoromethyl, --CN or OCF.sub.3);
• R.sup.7 is hydrogen or (C.sub.1-5)-alkyl;
• X is O
• Y and Z independently of each other are hydrogen, (C.sub.1-5)alkyl (C.sub.1-5)alkyloxy, benzyloxy (wherein the phenyl group is not substituted or contains 1, 2 or 3 substituents which are independently of each other (C.sub.1-5)alkyl, (C.sub.1-5)alkoxy, dimethylamine, halogen, trifluoromethyl, --CN or OCF.sub.3), OCF.sub.3, halogen, CF.sub.3, CN, CH.sub.2 NH.sub.2, CONH.sub.2, N--(C.sub.1-5 -alkyl).sub.2, NH--(C.sub.1-4)alkylcarbonyl, N--(C.sub.1-5)alkyl-N-(C.sub.1-4)alkylcarbonyl, NH.sub.2 or NH--(C.sub.1-5)alkyl, or R.sup.5 is an amine of formula IV ##STR362## wherein R.sup.6, R.sup.7, Y and Z have the above meanings
• R.sup.8 is hydrogen and R.sup.9 is hydroxy, (C.sub.1-5)alkoxy, phenyl-(C.sub.1-5)alkyloxy, naphthyl-(C.sub.1-5)alkyloxy or (C.sub.1-4)alkylcarbonyl, or wherein
• R.sup.8 and R.sup.9 are both oxygen or --OCH.sub.2 CH.sub.2 O--;
• and the chirality to C* may be R or S, and the pharmaceutically acceptable salts thereof.