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US 5,849,905 AGranted
Biologically active phosphotriester-type nucleosides and methods for preparing same
AssigneeCentre National De La Recherche Scientifique
InventorsGilles Gosselin, Jean-Louis Imbach, Christian Perigaud
Life of this patent
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Abstract
Compounds of formula RS--P(.dbd.O) (QR)--Nu where: R is a radical --(CH.sub.2)n-W--X; X is a radical --C(.dbd.Z) (Y) or --S--U; Z is O or S; W is O or S; Q is O or S; Y and U are an alkyl, aryl or saccharide radical which is optionally substituted with, for example, an OH, SH or NH group; n is equal to 1 to 4, preferably 1 or 2; and Nu is a radical consisting of a residue of a biologically active compound or the dephosphorylated residue of a compound which is biologically active when it bears a phosphate or phosphonate group.
Claims16
A compound having formula Ia:
- RS--P(.dbd.O) (QR)--Nu (Ia)
- in which:
- R is --(CH.sub.2)n-W--X;
- X is --C(.dbd.Z) (Y) or --S--U;
- Z is O or S;
- W is O or S;
- Q is O or S;
- Y and U are, independently, an alkyl, aryl or saccharide radical;
- n is 1 to 4;
- and
- Nu is a biologically active compound or the dephosphorylated residue of a compound which is biologically active when it bears a phosphate or phosphonate group.
8 more elements
Dependencies are inferred from the claim text.