Nucleic acid molecule encoding ciliary neurotrophic factor receptor
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsSamuel Davis, Stephen P. Squinto, Mark E. Furth, George D. Yancopoulos
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Abstract
The present invention relates to the ciliary neurotrophic factor (CNTF) receptor, and provides for CNTF receptor nucleic acid and amino acid sequences. It also relates to (i) assay systems for detecting CNTF activity; (ii) experimental model systems for studying the physiologic role of CNTF; (ii) diagnostic techniques for identifying CNTF-related neurologic conditions; (iv) therapeutic techniques for the treatment of CNTF-related neurologic and muscular conditions, and (v) methods for identifying molecules homologous to CNTF and CNTFR.
Claims10
An isolated nucleic acid molecule encoding a mammalian CNTF receptor, wherein the nucleic acid molecule is selected from the group consisting of:
- (a) a nucleic acid comprising the coding region of CNTF receptor as set forth in SEQ. ID. NO. 1;
- (b) a nucleic acid that hybridizes to SEQ. ID. NO. 1 at 68.degree. C. in the presence of 0.5 M NaPO.sub.4 (pH7), 1% bovine serum albumin, 7% SDS, 1 mM EDTA, and 100 .mu.g/ml sonicated denatured salmon sperm DNA and under wash conditions of 68.degree. C., in 3XSSC and 0.1% SDS, and
- (c) a nucleic acid differing from (a) and (b) due to the degeneracy of the genetic code.
An isolated nucleic acid molecule encoding the CNTF receptor having an amino acid sequence as depicted in SEQ. ID. NO. 2.
Dependencies are inferred from the claim text.