Nucleic acid-binding oligomers possessing C-branching for therapy and diagnostics
AssigneeBayer Aktiengesellschaft
InventorsAntonius Lobberding, Burkhard Mielke, Christoph Schwemler, Eckhard Schwenner, Udo Stropp, Wolfgang Springer, Axel Kretschmer, Thorsten Potter
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Abstract
The invention relates to nucleic acid-binding oligomers possessing C-branching of the general formula (I) ##STR1## and to the corresponding monomers, whose radicals have the meaning given in the description, and to their use as medicaments or diagnostic aids.
Claims12
A compound of the formula:
- ##STR23## in which R represents hydrogen or methyl;
- and
- BOC represents tert-butoxycarbonyl;
- optionally in the form of a racemic mixture, a stereoisomer mixture, or a purified stereoisomer.
A compound of the formula:
- ##STR24## in which R represents tert-butyl;
- and
- BOC represents tert-butoxycarbonyl;
- optionally in the form of a racemic mixture, a stereoisomer mixture, or a purified stereoisomer.
A compound of the formula:
- ##STR25## in which R represents hydrogen or tert-butyl;
- and
- X represents tert-butoxycarbonyl;
- or
- R represents hydrogen;
- and
- X represents 9-fluorenylmenthoxycarbonyl;
- optionally in the form of a racemic mixture, a stereoisomer mixture, or a purified stereoisomer.
A compound of the formula:
- ##STR26## in which R represents hydrogen;
- and
- BOC represents tert-butoxycarbonyl;
- optionally in the form of a racemic mixture, a stereoisomer mixture, or a purified stereoisomer.
A compound of the formula:
- ##STR27## in which R represents hydrogen or tert-butyl;
- and
- BOC represents tert-butoxycarbonyl;
- optionally in the form of a racemic mixture, a stereoisomer mixture, or a purified stereoisomer.
A compound of the formula:
- ##STR28## in which R represents hydrogen, methyl or benzyl;
- and
- BOC represents tert-butoxycarbonyl;
- optionally in the form of a racemic mixture, a stereoisomer mixture, or a purified stereoisomer.
A compound of the formula:
- ##STR29## in which R represents hydrogen;
- and
- BOC represents tert-butoxycarbonyl;
- optionally in the form of a racemic mixture, a stereoisomer mixture, or a purified stereoisomer.
A compound of the formula:
- ##STR30## in which R represents hydrogen or benzyl;
- and
- BOC represents tert-butoxycarbonyl;
- optionally in the form of a racemic mixture, a stereoisomer mixture, or a purified stereoisomer.
A compound of the formula:
- ##STR31## in which R represents hydrogen or benzyl;
- and
- BOC represents tert-butoxycarbonyl;
- optionally in the form of a racemic mixture, a stereoisomer mixture, or a purified stereoisomer.
A compound of the formula:
- ##STR32## in which R represents hydrogen or methyl;
- and
- BOC represents tert-butoxycarbonyl;
- optionally in the form of a racemic mixture, a stereoisomer mixture, or a purified stereoisomer.
A compound of the formula:
- ##STR33## in which R represents hydrogen or methyl;
- and
- BOC represents tert-butoxycarbonyl;
- optionally in the form of a racemic mixture, a stereoisomer mixture, or a purified stereoisomer.
A compound of the formula:
- ##STR34## in which R represents hydrogen or benzyl;
- and
- BOC represents tert-butoxycarbonyl;
- optionally in the form of a racemic mixture, a stereoisomer mixture, or a purified stereoisomer.
Dependencies are inferred from the claim text.