Polyethylene-protein conjugates
AssigneeHoffmann-La Roche Inc.
InventorsJohn Hakimi, Patricia Kilian, Perry Rosen
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Abstract
The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein which forms this conjugate.
Claims3
An ethylene glycol containing compound adapter to react with a protein to produce a protein conjugate of the formula ##STR10## said ethylene glycol containing compound having the formula ##STR11## wherein R is lower alkyl, R.sub.5 is H or lower alkyl, and n is any number such that the molecular weight of the protein conjugate, excluding the molecular weight of the protein, formed from said polyethylene glycol containing compound is from about 300 to about 30,000 daltons.
Dependencies are inferred from the claim text.