Polyesters
AssigneeNovartis AG
InventorMurat Acemoglu
Life of this patent
Estimating the term…
Abstract
A biodegradable and biocompatible polyester comprising (C.sub.3-10) alkylene carbonic acid ester units, each alkylene group being a C.sub.3 -alkylene group having 1 oxy substituent or a (C.sub.4-10) alkylene group having 2-8 oxy substituents, each of the oxy substituents occurring individually as a hydroxyl group or as a derivatized hydroxyl group comprising an ester or an ortho ester or an acetal residue. The polyesters may be used as matrices for the sustained release of pharmacologically active compounds, e.g. peptides or proteins, in the form of microparticles or implants.
Claims30
A biodegradable and biocompatible polyester comprising (C.sub.3-10) alkylene carbonic acid ester units, each alkylene group being a trimethylane group having 1 oxy substituent or a (C.sub.4-10) alkylene group having 2-8 oxy substituents, each of the oxy substituents occurring independently as a hydroxyl group or independently as a moiety comprising an ester or an ortho ester or an acetal moiety.
A pharmaceutical composition comprising:
- a drug compound;
- and a biodegradable and biocompatible polyester, mixed with the drug compound, the polyester having linear (C.sub.3-10) alkylene carbonic acid ester units in a homopolyester arrangement.
A pharmaceutical composition comprising:
- a drug compound;
- and a biodegradable and biocompatible polyester, mixed with the drug compound, the polyester having linear (C.sub.3-10) alkylene carbonic acid ester units with cholesterol residues.
A pharmaceutical composition comprising:
- a drug compound;
- and a biodegradable and a biocompatible polyester, mixed with the drug compound, the polyester having linear (C.sub.3-10) alkylene carbonic acid ester units having residues of a saturated or unsaturated (C.sub.2-20) fatty acid.
Dependencies are inferred from the claim text.