Tachykinins antagonists

Tachykinins antagonist of general formula (I)

• wherein:
• Y is benzene optionally substituted with one or more substituents independently selected from the group consisting of halogen, alkyl radicals containing from 1 to 6 carbon atoms optionally substituted with no more than three fluorine atoms, oxyalkyl radicals containing from 1 to 6 carbon atoms, optionally substituted with no more than three fluorine atoms, --NH.sub.2, --NHR.sub.10, --OR.sub.10, --N(R.sub.10).sub.2, --CONHR.sub.10, --COR.sub.10, --COOR.sub.10, --R.sub.10 COOR.sub.11, --OR.sub.10 COOR.sub.11, --NHCOR.sub.10, nitro-radicals wherein R.sub.10 and R.sub.11 are hydrogen or an alkyl radical, linear or branched, containing from 1 to 6 carbon atoms, with the proviso that R.sub.10 cannot be H in the case of R.sub.10 COOR.sub.11, OR.sub.10 COOR.sub.11, and R.sub.10 CONHR.sub.11 ;
• X.sub.1 and X.sub.2, are the same or different from each other, are selected from the group consisting of --CONR.sub.8, --NR.sub.8 CO--, --CH.sub.2 NR.sub.8 --, --SO.sub.2 NR.sub.8 --, wherein R.sub.8 is selected from the group consisting of hydrogen or an alkyl-chain, linear or modified, containing from 1 to 6 carbon atoms;
• X.sub.3 is selected from the group consisting of --CONR.sub.7, and --NR.sub.7 CO--, and R.sub.7 is selected from the group consisting of an alkyl radical with no more than 15 carbon atoms;
• R.sub.1, R.sub.2 and R.sub.3, independently from each other, are hydrogen, halogen, or OR.sub.12 wherein R.sub.12 is selected from the group consisting of hydrogen, --CH.sub.2 O(CH.sub.2).sub.2 OCH.sub.3 or --CH.sub.2 O(CH.sub.2).sub.2 OCH.sub.2 CH.sub.3 ;
• A is CH;
• n is a number from 0 to 2;
• R.sub.5 and R.sub.6 are, independently from each other, selected from the group consisting of an aryl-alkyl radical containing no more than 15 carbon atoms, wherein the aryl moiety is selected from the group consisting of biphenyl, benzene, and naphtene, optionally substituted on the ring with one or more substituents, independently from each other, selected from the group consisting of halogen, an alkyl-radical containing from 1 to 6 carbon atoms, optionally substituted with no more than three fluorine atoms, an oxyalkyl-radical containing from 1 to 6 carbon atoms, optionally substituted with no more than three fluorine atoms, an --NH.sub.2, --NHR.sub.11, --OR.sub.10, --N(R.sub.10).sub.2, --CONHR.sub.10, --COR.sub.10, --COOR.sub.10, --R.sub.10 COOR.sub.11, --OR.sub.10 COOR.sub.11, --CONHR.sub.10, --R.sub.10 CONHR.sub.11, --NHCOR.sub.10, nitro-radicals, wherein R.sub.10 and R.sub.11, are hydrogen or an alkyl-radical, linear or branched, containing from 1 to 6 carbon atoms with the proviso that R.sub.10 cannot be H in the case of R.sub.10 COOR.sub.11, OR.sub.10 COOR.sub.11 and R.sub.10 CONHR.sub.11.