(Mono) ethylenediaminenitroplatinum (IV) complexes with ligands of oxides of nitrogen as possible anti-tumor agents
AssigneeUniversity of South Florida
InventorsJay W. Palmer, Joseph A. Stanko, Said M. Sebti, Julia R. Burdge
Life of this patent
Estimating the term…
Abstract
The present invention discloses (mono)ethylenediaminenitroplatinum (IV) complexes of with ligands of oxides of nitrogen, and their synthesis, which, in vivo, may be reduced to produce "cisplatin" type platinum(II) antitumor complex and nitric oxide, which also reportedly has anti-tumor activity.
Claims12
A (mono)ethylenediaminenitroplatinum (IV) complex having the formula:
- ##STR1## or a stereoisomer thereof.
A (mono)ethylenediaminenitroplatinum (IV) complex having the formula:
- ##STR2## or a stereoisomer thereof.
A (mono)ethylenediaminenitroplatinum (IV) complex having the formula:
- ##STR3## or a stereoisomer thereof.
A (mono)ethylenediaminenitroplatinum (IV) complex having the formula:
- ##STR4## wherein said nitro ligands are trans to one another and said chloro ligands are cis to one another.
A (mono)ethylenediaminenitroplatinum (IV) complex having the formula:
- ##STR5## or a stereoisomer thereof.
A method for inhibiting the growth of cancer cells in a mammal using a (mono)ethylenediaminenitroplatinum (IV) complex having the formula:
- ##STR6## wherein a therapeutically effective amount of the (mono)ethylenediaminenitroplatinum (IV) complex or stereoisomer thereof, is administered to the mammal.
A method for inhibiting the growth of cancer cells in a mammal using a (mono)ethylenediaminenitroplatinum (IV) complex having the formula:
- ##STR7## or a stereoisomer thereof;
- wherein a therapeutically effective amount of the (mono)ethylenediaminenitroplatinum (IV) complex or stereoisomer thereof, is administered to the mammal.
Dependencies are inferred from the claim text.