Compound for treatment of cardiac arphythmia, synthesis, and methods of use
AssigneeARYx Therapeutics, Inc.
InventorPascal Druzgala
Life of this patent
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Abstract
Described is a novel compound and method, useful for treatment of cardiac arrhythmias, especially useful in patients with congestive heart failure (CHF). A process for synthesizing the novel compound is also described.
Claims16
A compound having the structure ##STR3## wherein R.dbd.H, OH, NH.sub.2, SH, halide, alkyl, O-alkyl, acyl, O-acyl, aryl, O-aryl, substituted amine, or substituted thiol;
- Y.dbd.OR.sub.1, wherein R.sub.1 is a straight or branched chain alkyl or heteroalkyl having 1 to 8 carbon atoms, a substituted or unsubstituted aryl or heteroaryl;
- or ##STR4## wherein R.sub.2 and R.sub.3 are independently selected from H, alkyl or heteroalkyl of 1 to 6 carbon atoms, or wherein N is part of a cyclic or heterocyclic group comprising morpholine, triazole, imidazole, pyrrolidine, piperidine, piperazine, pyrrole, dihydropyridine, aziridine, thiazolidine, thiazoline, thiadiazolidine, or thiadiazoline;
- and
- X is O;
- a derivative of said compound;
- or a salt of said compound.
A pharmaceutical composition for treating cardiac arrhythmia in an animal wherein said pharmaceutical composition comprises a compound having the structure ##STR5## wherein R.dbd.H, OH, NH.sub.2, SH, halide, alkyl, O-alkyl, acyl, O-acyl, aryl, O-aryl, substituted amine, or substituted thiol
- Y.dbd.OR.sub.1, wherein R.sub.1 is a straight or branched chain alkyl or heteroalkyl having 1 to 8 carbon atoms, a substituted or unsubstituted aryl or heteroaryl;
- or ##STR6## wherein R.sub.2 and R.sub.3 are independently selected from H, alkyl or heteroalkyl of 1 to 6 carbon atoms, or wherein N is part of a cyclic or heterocyclic group comprising morpholine, triazole, imidazole, pyrrolidine, piperidine, piperazine, pyrrole, dihydropyridine, aziridine, thiazolidine, thiazoline, thiadiazolidine, or thiadiazoline;
- X is O;
- a derivative of said compound;
- or a salt of said compound;
- and a pharmaceutically acceptable carrier.
A method for treating cardiac arrhythmia in an animal, wherein said method comprises administering an effective amount of a compound having the structure ##STR7## wherein R.dbd.H, OH, NH.sub.2, SH, halide, alkyl, O-alkyl, acyl, O-acyl, aryl, O-aryl, substituted amine, or substituted thiol,
- Y.dbd.OR.sub.1, wherein R.sub.1 is a straight or branched chain alkyl or heteroalkyl having 1 to 8 carbon atoms, a substituted or unsubstituted aryl or heteroaryl;
- or ##STR8## wherein R.sub.2 and R.sub.3 are independently selected from H, alkyl or heteroalkyl of 1 to 6 carbon atoms, or wherein N is part of a cyclic or heterocyclic group comprising morpholine, triazole, imidazole, pyrrolidine, piperidine, piperazine, pyrrole, dihydropyridine, aziridine, thiazolidine, thiazoline, thiadiazolidine, or thiadiazoline;
- and
- X is O;
- a derivative of said compound;
- or a salt of said compound.
Dependencies are inferred from the claim text.