Cell differentiation induction with mevalonate and mevalonolactone derivatives
AssigneeUniversity of New Mexico
InventorsTerence J. Scallen, Paul L. Mann
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Abstract
The invention provides cell modulators comprising certain biologically-active enantiomers of mevalonate and mevalonolactone derivatives. The compounds are broadly clinically useful, particularly in cancer management and treatment or immunological diseases or disorders.
Claims5
A method of stimulating humoral or cellular mediated immunity in a mammal comprising administering to said mammal a therapeutically effective amount of a compound of the formula:
- ##STR28## wherein A is ##STR29## wherein R.sub.1 is C.sub.1-6, Y is fluoro-, chloro- or bromo- and
- R' is hydrogen, a physiologically acceptable cation or cation complex, or a physiologically acceptable ester group.
A method of stimulating humoral or cellular mediated immunity in a mammal comprising administering to said mammal a therapeutically effective amount of a compound of the formula:
- ##STR30## wherein A is ##STR31## wherein R' is hydrogen, a physiologically-acceptable cation or cation complex, or a physiologically acceptable ester group.
A method of stimulating humoral or cellular mediated immunity in a mammal comprising administering to the mammal a therapeutically effective amount of a compound of the formula:
- ##STR32## wherein A is:
- ##STR33## wherein R' is hydrogen, a physiologically acceptable cation or cation complex, or a physiologically acceptable ester group.
A method of stimulating humoral or cellular mediated immunity in a mammal comprising administering to the mammal a therapeutically effective amount of a compound of the formula:
- ##STR34## wherein A is:
- ##STR35## wherein R' is hydrogen, a physiologically acceptable cation or cation complex, or a physiologically acceptable ester group.
Dependencies are inferred from the claim text.