Substituted benzoylguanidines process for their preparation, their use as a medicament or diagnostic, and pharmaceutical containing them

A benzoylguanidine of the formula I ##STR6## in which:

• R(1) is R(6)--CO;
• R(6) being (C.sub.1 -C.sub.8)-alkyl, (C.sub.1 -C.sub.8)-perfluoroalkyl, (C.sub.3 -C.sub.8)-alkenyl or --C.sub.n H.sub.2n --R(9),
• n being zero, 1, 2, 3 or 4,
• R(9) being (C.sub.3 -C.sub.8)-cycloalkyl, phenyl, biphenylyl or naphthyl, where the aromatic radicals are unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, CF.sub.3, methyl, methoxy and NR(10)R(11);
• R(10) and R(11) being H, (C.sub.1 -C.sub.4)-alkyl or (C.sub.1 -C.sub.4)-perfluoroalkyl;
• R(2) is (C.sub.1 -C.sub.9)-heteroaryl, which is linked via C or N and which is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, CF.sub.3, CH.sub.3, methoxy, hydroxyl, amino, methylamino and dimethylamino;
• or
• R(2) is SR(18), --OR(18), --NR(18)R(19) or --CR(18)R(19)R(20);
• R(18) is --C.sub.a H.sub.2a --(C.sub.1 -C.sub.9)-heteroaryl, which is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, CF.sub.3, CH.sub.3, methoxy, hydroxyl, amino, methylamino or dimethylamino;
• a is zero, 1 or 2;
• R(19) and R(20) independently of each other, are defined as R(18) or are hydrogen, (C.sub.1 -C.sub.4)-alkyl or (C.sub.1 -C.sub.4)-perfluoroalkyl;
• or
• R(2) is R(22)R(23)N--SO.sub.2 --;
• wherein R(22) and R(23) together are 4 or 5 methylene groups of which one CH.sub.2 group can be replaced by oxygen, S, NH, N--CH.sub.3 or N-benzyl;
• or
• R(2) is --C.tbd.CR(45), or --CR(46)=CR(45)
• wherein R(45) is (C.sub.1 -C.sub.9)-heteroaryl, which is unsubstituted or substituted by phenyl;
• and R(46) is hydrogen or methyl;
• R(3) is defined as R(1) or R(2);
• R(4) and R(5) are, independently of each other, defined as R(2);
• and pharmaceutically tolerated salts thereof.