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US 5,849,760 AGranted
2-(arylalkenyl)azacycloalkane derivatives as ligands for sigma receptors
AssigneeInstitut de Recherche Jouveinal
InventorsAlain Pierre Calvet, Henry Jacobelli, Jean-Louis Junien, Pierre Riviere, Fran.cedilla.ois-Joseph Roman
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Abstract
New 2-(arylalkenyl)azacycloalkane derivatives which are ligands for sigma receptors, of the formula (I) ##STR1## in which: Ar is aryl or heteroaryl, optionally mono- to trisubstituted, m has the value 1 or 2, n has the value 1 to 3, R is phenyl, or cycloalkyl containing 3 to 7 carbon atoms, their isomers and their addition salts. Medicinal drugs which are antipsychotic agents and are useful in gastroenterology.
Claims10
A sigma receptor ligand comprising a 2-(arylalkenyl) azacycloalkane compound of formula (I):
- ##STR13## in which:
- Ar is aryl or heteroaryl, optionally mono-, di- or tri-substituted with a halogen, nitro, lower alkyl, lower haloalkyl, lower alkoxy or lower haloalkoxy group;
- m has the value of 1 or 2;
- n has the value of 1 to 3;
- R is phenyl, optionally substituted with a halogen, nitro, lower alkyl, lower haloalkyl, lower alkoxy or lower haloalkoxy group or a cycloalkyl group containing 3 to 7 carbon atoms, an optical or geometric isomer thereof, a derivative in which an atom is replaced by an radioactive isotope, and an addition salt with a pharmaceutically acceptable acid.
2 more elements
Dependencies are inferred from the claim text.