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US 5,849,755 AGranted
3-amidochromanylsulfonyl(thio)ureas, processes for their preparation, their use, and pharmaceutical preparations comprising them
AssigneeHoechst Aktiengesellschaft
InventorsHeinrich Christian Englert, Uwe Gerlach, Dieter Mania, Wolfgang Linz, Heinz Gogelein, Erik Klaus
Life of this patent
Estimating the term…
Abstract
3-amidochromanylsulfonyl(thio)ureas of the formula (I): ##STR1## which are valuable pharmaceutically active compounds for the treatment of disturbances of the cardiovascular system, in particular for the treatment of arrhythmias, for preventing sudden cardiac death or for influencing a reduced contractility of the heart, and processes for their preparation, their use and pharmaceutical preparations comprising them.
Claims22
A compound of the formula (I) ##STR76## in which:
- R(1) is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms, alkoxyalkoxy having 1, 2, 3 or 4 carbon atoms independently of one another in each of the two alkoxy units, alkylmercapto having 1, 2, 3 or 4 carbon atoms, fluorine, chlorine, bromine, iodine or trifluoromethyl;
- R(2a), R(2b) and R(2c), which are identical or different, are hydrogen or alkyl having 1 or 2 carbon atoms;
- R(3) is hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms;
- Z is sulfur or oxygen;
- A is phenyl which is unsubstituted or substituted by up to three identical or different substituents selected from the group consisting of halogen, alkyl having 1 or 2 carbon atoms and alkoxy having 1 or 2 carbon atoms,
- or
- A is the radical of a saturated or unsaturated lactam of the formula ##STR77## in which B is alkenylene or alkylene having 3, 4, 5 or 6 carbon atoms, which radical is unsubstituted or substituted by up to three identical or different alkyl groups having 1, 2, 3 or 4 carbon atoms,
- or
- A is the radical of a bicyclic system selected from the group consisting of the formulae:
- ##STR78## in any of its stereoisomeric forms, or a mixture thereof in any ratio;
- or any of its physiologically acceptable salts.
8 more elements
Dependencies are inferred from the claim text.