6-(hydroxymethyl-ethyl)pyridines
AssigneeBayer Aktiengesellschaft
InventorsPeter Fey, Rolf Angerbauer, Delf Schmidt, Hilmar Bischoff, Wolfgang Kanhai, Martin Radtke, Wolfgang Karl
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Abstract
The 6-(hydroxymethyl-ethyl)pyridines are prepared by a process in which the 3-hydroxymethylpyridines which are hydroxyl-protected in the 6-position are oxidized to the 3-aldehyde, this is then converted into the corresponding oxoheptenoic acid derivative using a Wittig-Homer reaction, after this the oxo group is reduced to the hydroxyl group and then the isomers are separated by chromatography. The 6-(hydroxymethyl-ethyl)pyridines are suitable as active compounds in medicaments, in particular in medicaments having antiarteriosclerotic activity.
Claims9
A 6-(hydroxymethyl-ethyl)pyridine of the formula (I) ##STR40## in which R.sup.1 represents hydrogen or methyl, and
- R.sup.2 represents hydrogen or methyl,
- or a physiologically acceptable salt thereof.
Dependencies are inferred from the claim text.