US 5,849,747 A · N, n-disubstituted amic acid derivatives

Abstract

The present invention relates to a compound of the formula (I): ##STR1## wherein Ar.sup.1, Ar.sup.2, Ar.sup.3 and Ar.sup.4 represent an aryl group or a heteroaromatic ring group; A represents a hydrocarbon group which may be substituted; X and Y represent an oxygen atom, a sulfur atom, a carbonyl group or a group of the formula --CHR.sup.a -- (wherein R.sup.a is a hydrogen atom or a lower alkyl group) or --NR.sup.b -- (wherein R.sup.b is a hydrogen atom or a lower alkyl group), or X and Y together represent a vinylene group or an ethynylene group; R.sup.1, R.sup.2, R.sup.3, R.sup.8 and R.sup.9 represent a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a lower alkoxy group; R.sup.4 and R.sup.5 represent a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a nitro group, a cyano group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkyl group, a lower hydroxyalkyl group, a lower fluoroalkyl group or a lower alkoxy group; R.sup.6 is a lower alkyl group; and R.sup.7 is a hydrogen atom or a lower alkyl group, provided that when one of X and Y is an oxygen atom, a sulfur atom or a group of the formula --NR.sup.b --, the other is a carbonyl group or a group of the formula --CHR.sup.a --, its pharmaceutically acceptable salt or ester, and an antitumor agent containing it as an active ingredient.

Claims8

Dependent claims

A compound of the formula (I) or a pharmaceutically acceptable salt or ester thereof:

##STR99## wherein each of ##STR100## which are the same or different, is selected from the group consisting of phenyl, naphthyl and anthryl;
and heteroaromatic ring group which is a 5- or 6- membered monocyclic ring which contains --O--, --S-- or --N--;
A is a C.sub.2-8 saturated or unsaturated aliphatic hydrocarbon group which is unsubstituted or substituted by lower alkyl, hydroxyl, lower hydroxyalkyl, lower alkoxy, carboxyl, lower carboxyalkyl, phenyl, naphthyl or anthryl or alkyl-substituted phenyl, naphthyl or anthryl;
--X--Y-- is selected from the group consisting of --NR.sup.b --CO-- and --CO--NR.sup.b --, wherein R.sup.b is hydrogen or lower alkyl;
each of R.sup.1, R.sup.2, R.sup.3, R.sup.8 and R.sup.9, which are the same or different, is hydrogen, halogen, hydroxyl, lower alkyl or lower alkoxy;
each of R.sup.4 and R.sup.5 which are the same or different, is hydrogen, halogen, hydroxyl, amino, ritro, cyano, carboxyl, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, lower alkyl, lower hydroxyalkyl, lower fluoroalkyl or lower alkoxy;
R.sup.6 is lower alkyl;
and R.sup.7 is hydrogen or lower alkyl.

5 more elements

Dependencies are inferred from the claim text.

N, n-disubstituted amic acid derivatives

Life of this patent

N, n-disubstituted amic acid derivatives

Life of this patent

Abstract

Claims8