US 5,849,745 AGranted

N-benzylpiperazine compounds

AssigneeAdir et Compagnie

InventorsMichel Wierzbicki, Marie-Fran.cedilla.oise Boussard, Serge Labidalle, Daniel Guyot, Yves Rolland, Jean-Paul Tillement, Bernard Testa, Aime Crevat

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Abstract

A compound of formula (I): ##STR1## In which: R.sub.1 represents linear or branched (C.sub.1 -C.sub.6) alkyl, X represents oxygen or sulfur, R.sub.2 represents optionally substituted alkyl, alkoxy, optionally substituted phenyl, optionally substituted cycloalkyl, 4-(2,3-dithiacyclopent-1-yl)butyl, pyridyl or optionally substituted amino or any one of the groups as defined in the description, R.sub.3 represents hydrogen or cycloalkyl, formyl, optionally substituted phenyl, pyridyl or optionally substituted alkyl, the isomers thereof, the addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal compounds containing them are useful for the treatment of chronic or cellular ischemia.

A compound selected from those of formula (I) ##STR10## in which:

R.sub.1 represents linear or branched (C.sub.1 -C.sub.6)alkyl,
x represents oxygen or sulfur,
R.sub.2 represents linear or branched (C.sub.1 -C8)alkyl (optionally substituted with carboxyl or linear or branched (C.sub.1 -C.sub.6)alkoxycarbonyl), linear or branched (C.sub.1 -C.sub.6)alkoxy, a phenyl (optionally substituted with one or more halogen or linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, hydroxyl or trihalomethyl), (C.sub.3 -C.sub.7)cycloalkyl (optionally substituted with one or more phenyl which are themselves optionally substituted with one or more halogen or linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, hydroxyl or trihalomethyl), 4-(2,3-dithiacyclopent1-yl)butyl, pyridyl, amino (optionally substituted with one or two linear or branched (C.sub.1 -C.sub.6)alkyl), or any one of the following groups:
##STR11## wherein R.sub.3 represents hydrogen, (C.sub.3 -C.sub.7)cycloalkyl, formyl, phenyl (optionally substituted with one or more halogen or linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, hydroxyl or trihalomethyl), pyridyl, or linear or branched (C.sub.1 -C.sub.20)alkyl optionally substituted with one or more, identical or different, halogen or groups selected from the following:
phenyl optionally substituted with one or more halogen or linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, hydroxyl or trihalomethyl,
(C.sub.3 -C.sub.7)cycloalkyl (optionally substituted with one or more phenyl which are themselves optionally substituted with one or more halogen or linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, hydroxyl or trihalomethyl),
linear or branched (C.sub.1 -C.sub.6)alkoxy,
hydroxyl or
pyrrolidinyl,
the optical isomers thereof and the addition salts thereof with a pharmaceutically-acceptable acid or base.

7 more elements

Abstract

Claims10