US 5,849,741 A · Fused pyridazine compounds

Abstract

A fused pyridazine compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof which exhibits an inhibitory activity against cyclic GMP phosphodiesterase (hereinafter referred to as "cGMP-PDE"). The compounds are useful as preventive and therapeutic agents for diseases for which a cGMP-PDE inhibiting action is efficacious, for example, ischemic heart diseases such as angina pectoris, myocardial infarct and chronic and acute cardiac failure, pulmonary hypertension, arteriosclerosis and bronchial asthma. ##STR1##

Claims5

Dependent claims

A fused pyridazine compound represented by formula (II) below or a pharmacologically acceptable salt thereof:

##STR101## wherein n is 1;
R.sup.1 is a cyano group;
R.sup.2 and R.sup.3 represent each independently a halogen atom or methoxy group;
the bond illustrated by the line - - - represents a double bond;
X is a nitrogen atom;
and
Y is a .dbd.C--Z group, wherein Z is a halogen atom or a group represented by the formula:
##STR102##

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

08/619,621Filed 9 Apr 1996

Priority

JP 6-1871289 Aug 1994

Granted

15 Dec 1998

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

C07D 231/12
Having two or three double bonds between ring members or between ring members and non-ring members: with only hydrogen atoms, hydrocarbon or…
A61P 9/00
Drugs for disorders of the cardiovascular system
C07D 233/56
Having two double bonds between ring members or between ring members and non-ring members: with only hydrogen atoms or radicals containing only…
C07D 237/34
Phthalazines: with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Fused pyridazine compounds

Life of this patent

Fused pyridazine compounds

Life of this patent

Abstract

Claims5