Loading patent…
AssigneeThe Regents of the University of California
InventorsSandra Reading Chaplan, Flemming Winther Bach, Tony Lee Yaksh
Estimating the term…
Compositions and methods for alleviating pain (in particular, neuropathic pain) in a mammalian patient, wherein an effective amount of a physiologically-acceptable salt of a compound of the general formula ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 is independently selected from the group consisting of hydrogen, hydroxyl, acyl, alkoxyl, alkyl, aryl, alkylaryl, arylalkyl, hydroxyalkyl, hydroxyaryl, alkoxyalkyl, alkoxyaryl and NR.sup.8 R.sup.9, in which each of R.sup.8 and R.sup.9 is independently selected from the group consisting of hydrogen, alkyl, aryl, acyl, alkylaryl, arylalkyl, hydroxyalkyl, hydroxyaryl, alkoxyalkyl and alkoxyaryl, with the proviso that at least one of R.sup.1, R.sup.2 and R.sup.3 is hydroxyl; each of R.sup.4 and R.sup.5 is independently selected from the group consisting of hydrogen, halogen and lower alkyl; A is --C(.dbd.O)O-- or NR.sup.10 C(.dbd.O)--, in which R.sup.10 is selected from the group consisting of hydrogen, alkyl, aryl, alkylaryl, arylalkyl, hydroxyalkyl, hydroxyaryl, alkoxyalkyl and alkoxyaryl; B is --(CR.sup.11 R.sup.12).sub.n --, in which each of R.sup.11 and R.sup.12 is independently selected from the group consisting of hydrogen, halogen, hydroxyl, alkoxyl, alkyl, aryl, acyl, alkylaryl, arylalkyl, hydroxyalkyl, hydroxyaryl, alkoxyalkyl and alkoxyaryl, and n is an integer from 1 to 5; and C is NR.sup.6 R.sup.7, in which each of R.sup.6 and R.sup.7 is independently selected from the group consisting of hydrogen, alkyl, aryl, acyl, alkylaryl, arylalkyl, hydroxyalkyl, hydroxyaryl, alkoxyalkyl and alkoxyaryl, or R.sup.6 and R.sup.7 together form a heterocycle or substituted heterocycle selected from the group consisting of piperidyl, N-alkylpiperidyl, piperazinyl, N'-alkylpiperazinyl, morpholinyl and N-alkylmorpholinyl, is administered in a pharmaceutically acceptable carrier or excipient.
A method for alleviating neuropathic pain in a mammalian patient, comprising administering to the patient an amount effective to alleviate neuropathic pain of a physiologically acceptable salt of at least one compound of general formula I ##STR6## wherein each of R.sup.1, R.sup.2 and R.sup.3 is independently selected from the group consisting of hydrogen, hydroxyl, acyl, alkoxyl, alkyl, aryl, alkylaryl, arylalkyl, hydroxyalkyl, hydroxyaryl, alkoxyalkyl, alkoxyaryl and NR.sup.8 R.sup.9, in which each of R.sup.8 and R.sup.9 is independently selected from the group consisting of hydrogen, alkyl, aryl, acyl, alkylaryl, arylalkyl, hydroxyalkyl, hydroxyaryl, alkoxyalkyl and alkoxyaryl, with the proviso that at least one of R.sup.1, R.sup.2 and R.sup.3 is hydroxyl;
A composition for alleviating neuropathic pain in a mammalian patient, consisting essentially of physiologically active material and suitable carrier or excipient material, said physiologically active material comprising an amount effective to alleviate neuropatic pain of a physiologically-acceptable salt of at least one compound of general formula I ##STR7## wherein each of R.sup.1, R.sup.2 and R.sup.3 is independently selected from the group consisting of hydrogen, hydroxyl, acyl, alkoxyl, alkyl, aryl, alkylaryl, arylalkyl, hydroxyalkyl, hydroxyaryl, alkoxyalkyl, alkoxyaryl and NR.sup.8 R.sup.9, in which each of R.sup.8 and R.sup.9 is independently selected from the group consisting of hydrogen, alkyl, aryl, acyl, alkylaryl, arylalkyl, hydroxyalkyl, hydroxyaryl, alkoxyalkyl and alkoxyaryl, with the proviso that at least one of R.sup.1, R.sup.2 and R.sup.3 is hydroxyl;
A method for alleviating pain in a mammalian patient, comprising administering to the patient an amount effective to alleviate pain of a physiological-acceptable salt of 3-hydroxylidocaine.
A composition for alleviating pain in a mammalian patient, consisting essentially of physiologically active material and a suitable carrier or excipient, said physiologically active material comprising an amount effective to alleviate pain of a physiological-acceptable salt of 3-hydroxylidocaine.
A composition for alleviating neuropathic pain in a mammalian patient, consisting essentially of physiologically active material and suitable carrier or excipient material, said physiologically active material comprising an amount effective to alleviate neuropatic pain of a physiologically-acceptable salt of at least one compound of general formula I ##STR8## wherein each of R.sup.1, R.sup.2 and R.sup.3 is independently selected from the group consisting of hydrogen, hydroxyl, acyl, alkoxyl, alkyl, aryl, alkylaryl, arylalkyl, hydroxyalkyl, hydroxyaryl, alkoxyalkyl, alkoxyaryl and NR.sup.8 R.sup.9, in which each of R.sup.8 and R.sup.9 is independently selected from the group consisting of hydrogen, alkyl, aryl, acyl, alkylaryl, arylalkyl, hydroxyalkyl, hydroxyaryl, alkoxyalkyl and alkoxyaryl, with the proviso that at least one of R.sup.1, R.sup.2 and R.sup.3 is hydroxyl;
Dependencies are inferred from the claim text.