Phenol compound having antioxidative activity and the process for preparing the same

A compound selected from

• 2-›3-(3-pyridylmethyl)ureido!-4-methoxy-6-tert-butylphenol,
• 2-(3-cyclohexyl-3-phenylmethylureido)-4-methoxy-6-tert-butylphenol,
• 2-›3-cycloheptyl-3-(4-dimethylaminophenyl)ureido!-4-methoxy-6-tert-butylphe nol,
• 2-›3,3-di(pyridylmethyl)ureido!-4-methoxy-6-tert-butylphenol,
• 2-›4-(4-aminophenyl)piperazin-1-yl!amido-4-methoxy-6-tert-butylphenol,
• 2-›3-(2-cyclohexylethyl)-3-(4-dimethylaminophenyl)ureido!-4-methoxy-6-tert- butylphenol, and
• 2-›3-(4-pyridylmethyl)-3-(3-pyridyl)ureido!-4-methoxy-6 -tert-butylphenol.

A phenol compound represented by the formula (1):

• ##STR478## wherein R.sup.0 represents a hydrogen atom, an alkyl group, a substituted alkyl group, an alkyloxy group, or a substituted alkyloxy group;
• R.sup.1 represents an alkyl group or a substituted alkyl group;
• R.sup.2 represents an alkyl group, substituted alkyl group, an alkyloxy group, or a substituted alkyloxy group;
• OR.sup.3 represents a hydroxyl group or a hydroxyl group which is protected by an acyl group, a lower alkyloxy-lower alkyl group, a lower alkyloxycarbonyl group, a lower alkylcarbonyloxy-lower alkyl group or an aralkyl group;
• R.sup.4 represents a hydrogen atom, a lower alkyl group, a substituted lower alkyl group, an acyl group, or a substituted acyl group;
• W represents O, S or NR.sup.7, wherein R.sup.7 represents a hydrogen atom, an alkyl group, an aryl group, a hydroxyl group or an alkyloxy group;
• a group of the formula (2):
• ##STR479## which represents a mono- or di-substituted amino group or monocyclic or dicyclic heterocyclic group or a 5 to 10-membered monocyclic or dicyclic heterocyclic group which is mono-, di- or tri-substituted by 1 to 3 substituents selected from the group consisting of a halogen atom, an alkyl group, hydroxyl group, a kydroxyalkyl group, an alkyloxy group, oxo group, carboxyl group, an alkyloxycarbonyl group, a phenylalkylaminoalkyl group, phenyl group, a halogenophenyl group, an aminophenyl group, a nitrophenyl group, an aminophenylalkenyl group, an aminoalkyl group, an aminophenylalkyl group, an N,N-diaminoalkylaminophenylalkyl group, an N-arylureidoalkyl group, a morpholinylphenylalkyl group, a pyridylalkyl group, a benzimidazolylalkyl group, a hydroxyphenyl group, a diaminophenyl group, an N-alkylaminophenyl group, an N,N-dialkylaminophenyl group, an amidinophenyl group, a piperadinophenyl group, a morpholinophenyl group, pyrrolidinyl group, piperidyl group, indolyl group, pyrimidinyl group, benzimidazolyl group and pyridyl group,
• or a pharmaceutically acceptable salt thereof.