Indole derivatives and medical application thereof

An indole derivative represented by the following general formula (I) or a pharmacologically acceptable acid addition salt thereof:

• ##STR19## wherein:
• R.sup.1 is hydrogen, an alkyl having 1 to 5 carbon atoms, a cycloalkylalkyl having 4 to 7 carbon atoms, a cycloalkenylalkyl having 5 to 7 carbon atoms, an aryl having 6 to 12 carbon atoms, an aralkyl having 7 to 13 carbon atoms, an alkenyl having 3 to 7 carbon atoms, a furan-2-yl-alkyl in which the alkyl has 1 to 5 carbon atoms, or a thiophene-2-yl-alkyl in which the alkyl has 1 to 5 carbon atoms;
• R.sup.2 is hydrogen, hydroxy, an alkoxy having 1 to 5 carbon atoms, or an alkanoyloxy having 1 to 5 carbon atoms;
• R.sup.3 is hydrogen, hydroxy, an alkoxy having 1 to 5 carbon atoms, an alkanoyloxy having 1 to 5 carbon atoms, or an aralkyloxy having 7 to 13 carbon atoms;
• --X-- is a crosslinkage comprising 2 to 5 carbon atoms in which at least one of the carbon atoms may be replaced with a nitrogen atom, an oxygen atom, or a sulfur atom;
• m is an integer from 0 to 3;
• n is an integer from 0 to 10;
• each of m R.sup.4 groups and n R.sup.5 groups is individually fluoro, chloro, bromo, iodo, nitro, an alkyl having 1 to 5 carbon atoms, an alkoxy having 1 to 5 carbon atoms, trifluoromethyl, trifluoromethoxy, cyano, phenyl, a hydroxyalkyl having 1 to 3 carbon atoms, isothiocyanato, SR.sup.6, SOR.sup.6, SO.sub.2 R.sup.6, (CH.sub.2).sub.p OR.sup.6, (CH.sub.2).sub.p CO.sub.2 R.sup.6, SO.sub.2 NR.sup.7 R.sup.8, CONR.sup.7 R.sup.8, (CH.sub.2).sub.p NR.sup.7 R.sup.8, or (CH.sub.2).sub.p N(R.sup.7)COR.sup.8, in which p is an integer from 0 to 5;
• R.sup.6 is an alkyl having 1 to 5 carbon atoms;
• each of R.sup.7 and R.sup.8 is individually hydrogen, an alkyl having 1 to 5 carbon atoms, or a cycloalkylalkyl having 4 to 7 carbon atoms;
• and among the above m R.sup.4 groups and n R.sup.5 groups, at least one pair of adjacent R.sup.4 groups, adjacent R.sup.5 groups, and one R.sup.4 and one R.sup.5 groups may be linked to form a benzene, pyridine, cyclopentane, cyclohexane, or cycloheptane condensed ring;
• R.sup.9 is hydrogen, alkyl having 1 to 5 carbon atoms, an alkenyl having 1 to 5 carbon atoms, an aralkyl having 7 to 13 carbon atoms, a hydroxyalkyl having 1 to 3 carbon atoms, (CH.sub.2).sub.p OR.sup.6, or (CH.sub.2).sub.p CO.sub.2 R.sup.6, in which definitions of p and R.sup.6 are the same as above;
• R.sup.10 and R.sup.11 are linked to form an --O--, --S--, or --CH.sub.2 -- group;
• or R.sup.10 is hydrogen while R.sup.11 is independently hydrogen, hydroxy, an alkoxy having 1 to 5 carbon atoms, or an alkanoyloxy having 1 to 5 carbon atoms;
• and
• the compound expressed by the general formula (I) may be a (+) form, a (-) form, or a (.+-.) form.