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US 5,849,730 AGranted
Process for preparing demethylrapamycins
AssigneePfizer Inc.
InventorsMark A. Guadliana, Susan J. Truesdell
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Abstract
A compound of the formula (IV) ##STR1## and a process for preparing the compound of formula (IV). Also disclosed is a process for preparing C-16-demethylrapamycin and C-39-demethylrapamycin. The process of this invention comprises fermenting Actinoplanes sp. ATCC 63771 in the presence of rapamycin and isolating the products produced thereby.
Claims4
A compound according to the formula ##STR4##
A process for preparing a compound according to the formula ##STR5## comprising:
- (a) fermenting Actinoplanes sp. ATCC 53771 in the presence of a compound of the formula ##STR6## in a suitable growth medium and isolating said compound of formula (IV).
Dependencies are inferred from the claim text.