Use of hydrolyzed cocoa butter for percutaneous absorption
AssigneeHershey Foods Corporation
InventorsBarry L. Zoumas, Stanley M. Tarka, J. Michael McKim, Bryan J. Simmons, James G. Marks, Jr., Michael Santanna
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Abstract
The present invention relates to a pharmaceutical formulation prepared from medicaments selected from the group consisting of retinoids, corticosteroids, vitamin D or .alpha. or .beta.-hydroxy acids admixed with cocoa butter or partially hydrolyzed cocoa butter emulsion.
Claims31
A topical composition for enhancing the skin penetration of a pharmaceutically active agent in a mammal, wherein the pharmaceutically active agent is a retinoid, steroid, Vitamin D or .alpha.- or .beta.-hydroxy carboxylic acid comprising a safe and pharmaceutically effective amount of said pharmaceutically active agent admixed with a penetration enhancing effective amount of a partially hydrolyzed cocoa butter emulsion and a pharmaceutically carrier thereof, wherein said partially hydrolyzed cocoa butter emulsion comprises water, fatty acid and unsaponified cocoa butter, the partially hydrolyzed cocoa butter emulsion contains an aqueous and non-aqueous phase, said fatty acid comprises palmitic acid, stearic acid, and oleic acid, the amount of palmitic acid present in the non-aqueous phase of the emulsion ranges from about 10% to about 20% by weight, the amount of stearic acid in the non-aqueous phase of the emulsion ranges from about 15% to about 25% by weight and the amount of oleic acid in the non-aqueous phase ranges from about 17% to about 27% by weight.
A topical composition for enhancing the skin penetration of a pharmaceutically active agent in a mammal, wherein the pharmaceutically active agent is a retinoid, steroid, vitamin D or .alpha.- or .beta.-hydroxy carboxylic acid comprising a safe and effective amount of said pharmaceutically active agent admixed with a penetration enhancing effective amount of a partially hydrolyzed cocoa butter emulsion, wherein said partially hydrolyzed cocoa butter emulsion comprises water, stearic acid, palmitic acid, oleic acid and unsaponified cocoa butter and wherein the amount of water present in the partially hydrolyzed cocoa butter emulsion ranges from about 70%-90% by weight.
A topical composition for enhancing the skin penetration of a pharmaceutical active agent in a mammal, wherein the pharmaceutically active agent is a retinoid, steroid, Vitamin D or .alpha.- or .beta.-hydroxy carboxylic acid comprising a safe and effective amount of said pharmaceutically active agent admixed with a penetration enhancing effective amount of a partially hydrolyzed cocoa butter emulsion and a pharmaceutical carrier therefor, wherein said partially hydrolyzed cocoa butter emulsion contains in the non-aqueous portion thereof about 4 to about 6% stearic acid (w/w), about 4.5% to about 6.5% oleic acid (w/w) and about 10 to about 15% triglyceride (w/w).
Dependencies are inferred from the claim text.