Targeting complexes and use thereof
AssigneeMedical Research Council
InventorFranklin Grosveld
Life of this patent
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Abstract
The invention relates to a composition including a targeting complex containing a component of an effector system and a ligand capable of targeting a cell surface marker in association with at least one further targeting complex containiing a further component of the effector system and a ligand capable of targeting a cell surface marker which is a different cell surface marker to that targeted by at least one of the other targeting complexes, wherein the desired activity of the effector system is dependent on the selective internalization and functional cooperation of the components thereof.
Claims8
A composition for producing a desired biological activity in a host cell, comprising a plurality of targeting complexes comprising
- a first targeting complex comprising a ligand which targets a first cell surface marker of a host cell and a first component of an effector system, and
- a second targeting complex comprising a second ligand which targets a second cell surface marker of a host cell and a second component of the effector system, wherein said second cell surface marker is different from said first cell surface marker, wherein selective internalization and functional cooperation of the components of the effector system results in said biological activity.
Dependencies are inferred from the claim text.