O-sulfated gangliosides and lyso-ganglioside derivatives

A compound having a sulfated hydroxyl group selected from the group consisting of mono-sulfated derivatives of:

• N-acetyl-lyso-GM.sub.1,
• N-dichloroacetyl-lyso-GM.sub.1,
• N-phenylacetyl-lyso-GM.sub.1,
• N-propionyl-lyso-GM.sub.1,
• N-trimethylacetyl-lyso-GM.sub.1,
• N-trimethoxybenzoyl-lyso-GM.sub.1,
• N-nicotinoyl-lyso-GM.sub.1,
• N-capronyl-lyso-GM.sub.1,
• N-octanoyl-lyso-GM.sub.1,
• N-decanoyl-lyso-GM.sub.1,
• N-undecanoyl-lyso-GM.sub.1,
• N-4-chlorobenzoyl-lyso-GM.sub.1,
• N-4-benzoyl-lyso-GM.sub.1, and
• N-2-bromoacetyl-lyso-GM.sub.1.

A compound having one or more sulfated hydroxyl groups selected from the group consisting of mono- and poly-sulfated derivatives of:

• N'-acetyl-N'-lyso-GM.sub.1,
• N'-dichloroacetyl-N'-lyso-GM.sub.1,
• N'-phenylacetyl-N'-lyso-GM.sub.1,
• N'-propionyl-N'-lyso-GM.sub.1,
• N'-trimethylacetyl-N'-lyso-GM.sub.1,
• N'-trimethoxybenzoyl-N'-lyso-GM.sub.1,
• N'-nicotinoyl-N'-lyso-GM.sub.1,
• N'-capronyl-N'-lyso-GM.sub.1,
• N'-octanoyl-N'-lyso-GM.sub.1,
• N'-decanoyl-N'-lyso-GM.sub.1,
• N'undecanoyl-N'-lyso-GM.sub.1,
• N'-4-chlorobenizoyl-N'-lyso-GM.sub.1,
• N'-4-benzoyl-lyso-GM.sub.1, and
• N'-2-bromoacetyl-lyso-GM.sub.1, wherein the molar ratio of sulfate groups to sialic residues is from 1:1 to 5:1.

A compound having one or more sulfated hydroxyl groups selected from the group consisting of mono- and polysulfated derivatives of

• N,N'-diacetyl-N,N'-dilyso-GM.sub.1,
• N,N'-di(dichloroacetyl)-N,N'-dilyso-GM.sub.1,
• N,N'-di(phenylacetyl)-N,N'-dilyso-GM.sub.1,
• N,N'-di(propionyl)-N,N'-dilyso-GM.sub.1,
• N,N'-di(trimethylacetyl)-N,N'-dilyso-GM.sub.1,
• N,N'-di(trimethoxybenzoyl)-N,N'-dilyso-GM.sub.1,
• N,N'-di(nicotinoyl)-N,N'-dilyso-GM.sub.1,
• N,N'-di(capronyl)-N,N'-dilyso-GM.sub.1,
• N,N'-di(octanoyl)-N,N'-dilyso-GM.sub.1,
• N,N'-di(decanoyl) -N,N'-dilyso-GM.sub.1,
• N,N'-di(undecanoyl)-N,N'-dilyso-GM.sub.1,
• N,N'-di(4-chlorobenzoyl)-N,N'-dilyso-GM.sub.1,
• N,N'-di(4-benzoyl)-N,N'-dilyso-GM.sub.1, and
• N,N'-di(2-bromoacetyl)-N,N'-dilyso-GM.sub.1, wherein the molar rtio of sulfate groups to sialic residues is from 1:1 to 5:1.

Pharmaceutical preparations containing as the active ingredients a compound selected from the group consisting of

• O-SULFATED GM.sub.1
• O-POLYSULFATED GM.sub.1
• O-SULFATED GM.sub.2 and
• O-SULFATED GM.sub.3
• in association with a pharmaceutically acceptable excipient, wherein the molar ratio of sulfate groups to sialic residues is from 1:1 to 5:1.