Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof
OwnerRichard M. Synenki, Peter M. Rubinelli +2inventors
InventorsRichard M. Synenki, Peter M. Rubinelli, Henry E. Auer, James E. Seely
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Abstract
The present invention provides a stable and bioactive recombinant small-loop modified somatotropin which has its small-loop cysteines changed to other amino acids or deleted altogether and a method for producing such a small-loop modified somatotropin. Also provided by the present invention are DNA sequences coding for such small-loop modified somatotropins, plasmids containing such sequences, and organisms containing such plasmids. Furthermore, pharmaceutical compositions including small-loop modified somatotropins and methods for using such pharmaceutical compositions are disclosed.
Claims4
A stable and bioactive somatotropin pharmaceutical composition comprising a small-loop modified .DELTA.7 porcine somatotropin, and a pharmaceutically acceptable carrier therefor, wherein said somatotropin is .DELTA.7 psT asn (173) ser (181).
A .DELTA.7 porcine somatotropin having the amino acid sequence encoded for by the following DNA sequence:
- ##STR1##
Dependencies are inferred from the claim text.