Morphogen-induced liver regeneration
AssigneeCreative BioMolecules, Inc.
InventorsThangavel Kuberasampath, David C. Rueger, Hermann Oppermann, Roy H. L. Pang, Charles M. Cohen
Life of this patent
Estimating the term…
Abstract
Disclosed are therapeutic treatment methods, compositions and devices for maintaining liver function in a mammal, including methods, compositions and devices for regenerating lost or damaged hepatic tisse, enhancing viability and integration of hepatic tissue and organ transplants, and correcting liver function deficiencies. The methods, compositions and devices on this invention all provide a therapeutically effective morphogen concentration to the hepatic cells to be treated.
Claims19
A method for inducing regeneration of lost or damaged hepatic tissue in a mammal, the method comprising the step of:
- administering a morphogen to a locus of said damaged or lost tissue under conditions such that said morphogen induces tissue-specific regeneration thereat,
- said morphogen comprising a dimeric protein having the following properties:
- inducing a cascade of tissue-specific morphogenesis culminating in the formation of mammalian bone or liver tissue, and
- comprising a pair of folded polypeptides, the amino acid sequence of each of which comprises a sequence sharing at least 70% amino acid sequence homology with the C-terminal seven-cysteine domain of human OP-1, residues 38-139 of Seq. ID No. 5.
A method for inducing regeneration of lost or damaged hepatic tissue in a mammal, the method comprising the step of:
- administering a morphogen to a locus of said damaged or lost tissue under conditions such that said morphogen induces tissue-specific regeneration thereat,
- said morphogen comprising a dimeric protein having the following properties:
- inducing a cascade of tissue-specific morphogenesis culminating in the formation of mammalian bone or liver tissue, and
- comprising a pair of polypeptides, the amino acid sequence of each of which comprises a sequence defined by Generic Sequence 6, Seq.
- ID No. 31.
Dependencies are inferred from the claim text.