Diagnostic assays for Alzheimer's disease
AssigneeThe McLean Hospital Corporation
InventorsRalph Nixon, Toshiyuki Honda
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Abstract
The invention provides a method of diagnosing Alzheimer's disease in a human patient by measuring the amount of p33 present in a biological sample from a patient who may have Alzheimer's disease relative to the amount of p33 in a control sample from an unaffected human. Also included in the invention are diagnostic kits for Alzheimer's disease and methods of screening for effective therapeutics for Alzheimer's disease.
Claims5
A method of detecting Alzheimer's disease in a human patient, said method comprising using an antibody that specifically recognizes Annexin V in an immunoassay to measure the amount of p33 present in a biological sample of said patient relative to the amount of p33 in a control sample from an unaffected human, a relative level of p33 in said sample from said patient 50 percent above the level of p33 in said control sample indicating a diagnosis of Alzheimer's disease in said patient, said immunoassay allowing a differentiation of protein mass.
Dependencies are inferred from the claim text.