Regulators of UCP3 gene expression
AssigneeTularik Inc.
InventorsM. Catherine Amaral, Ning Zhang, Jin-Long Chen
Life of this patent
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Abstract
The invention relates to regulators of UCP3 gene transcription, including novel UCP3 transcriptional promoters. UCP3 gene promoters are used in diagnosis and pharmaceutical development. In particular, transfected cells comprising UCP3 gene promoters operably linked to a reporter are used in high-throughput pharmaceutical screens.
Claims19
An isolated nucleic acid composing SEQ ID NO:1 or 2, or a fragment thereof at least 50 bp in length comprising at least one sequence selected from the group consisting of SEQ ID NO:1, nucleotides 411-460;
- SEQ ID NO:1, nucleotides 461-510;
- SEQ ID NO:1, nucleotides 401-563;
- SEQ ID NO:1, nucleotides 319-326;
- SEQ ID NO:1, nucleotides 98-104;
- SEQ ID NO:1, nucleotides 49-56;
- SEQ ID NO:1, nucleotides 49-104;
- SEQ ID NO:1, nucleotides 547-554;
- SEQ ID NO:1, nucleotides 1-1548;
- SEQ ID NO:1, nucleotides 200-1548;
- SEQ ID NO:1, nucleotides 1090-1548;
- SEQ ID NO:1, nucleotides 1285-1548;
- SEQ ID NO:1, nucleotides 1-1090;
- SEQ ID NO:1, nucleotides 1285-1461;
- SEQ ID NO:2, nucleotides 1-5080;
- SEQ ID NO:2, nucleotides 3751-5080;
- SEQ ID NO:2, nucleotides 3940-5080;
- SEQ ID NO:2, nucleotides 4580-5080;
- SEQ ID NO:2, nucleotides 4840-5080;
- SEQ ID NO:2, nucleotides 1-3571;
- SEQ ID NO:2, nucleotides 3940-4935;
- and SEQ ID NO:2, nucleotides 4843-4862.
An isolated nucleic acid comprising SEQ ID NO:1 or 2, or a fragment thereof at least 50 bp in length comprising at least one sequence selected from the group consisting of SEQ ID NO 1, nucleotides 401-563;
- SEQ ID NO:1, nucleotides 1-1548;
- SEQ ID NO:1, nucleotides 200-1548;
- SEQ ID NO:
- 1, nucleotides 1-1090;
- SEQ ID NO:2, nucleotides 1-5080;
- SEQ ID NO:2, nucleotides 3751-5080;
- SEQ ID NO:2, nucleotides 3940-5080;
- SEQ ID NO:2, nucleotides 4580-5080;
- SEQ ID NO:2, nucleotides 4840-5080;
- SEQ ID NO:2, nucleotides 1-3571;
- and SEQ ID NO:2, nucleotides 3940-4935.
An isolated nucleic acid comprising SEQ ID NO:1 or 2.
Dependencies are inferred from the claim text.