Nucleic acid encoding a NF-.kappa.B activation regulatory protein, I.kappa.B.beta.
AssigneeYale University
InventorSankar Ghosh
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Abstract
The present invention provides a novel polypeptide, I.kappa.B-.beta., which binds to and affects NF-.kappa.B gene activation. Also provided is the nucleotide sequence encoding I.kappa.B-.beta. and methods of identifying compositions which affect I.kappa.B-.beta./NF-.kappa.B complexes. Methods of treatment of disorders associated with NF-.kappa.B induced gene activation are also described herein.
Claims9
An isolated nucleic acid sequence which encodes the amino acid sequence set forth as SEQ ID NO:2.
The nucleic acid sequence of claim wherein the nucleic acid sequence comprises the sequence set forth as SEQ ID NO:1.
An isolated nucleic acid sequence, wherein the nucleic acid sequence is selected from the group consisting of:
- (a) the nucleic acid sequence set forth as SEQ ID NO:1;
- (b) the nucleic acid sequence set forth as SEQ ID NO:1, which nucleic acid sequence is an RNA sequence;
- and
- (c) the nucleic acid sequence that is the full length complement of the nucleic acid sequence set forth as SEQ ID NO:1.
Dependencies are inferred from the claim text.