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AssigneeMillennium Pharmaceuticals, Inc.
InventorDean A. Falb
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The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease. Moreover, the present invention provides methods for the diagnostic monitoring of patients undergoing clinical evaluation for the treatment of cardiovascular disease, and for monitoring the efficacy of compounds in clinical trials. Additionally, the present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions.
An isolated polynucleotide comprising a nucleotide sequence (a) encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:40, or (b) encoding an rchd528 polypeptide whose sequence is encoded by the cDNAs contained in the plasmids pFCHD528A, pFCHD528B, and pFCHD528C, as deposited with the American Type Culture Collection as Accession Nos:
An isolated polynucleotide comprising the nucleotide sequence of (a) the rchd528 cDNA shown in SEQ ID NO:7, or (b) the rchd528 cDNA contained in the plasmids pFCHD528A, pFCHD528B, and pFCHD528C, as deposited with the American Type Culture Collection as Accession Nos:
An isolated polynucleotide comprising the nucleotide sequence of (a) the rchd528 polypeptide coding region from nucleotide residue number 19 to 4461 of SEQ ID NO:7, or (b) the polypeptide coding region of the rchd528 cDNA contained in the plasmids pFCHD528A, pFCHD528B, and pFCHD528C as deposited with the American Type Culture Collection as Accession Nos:
A polynucleotide fragment that encodes the amino acid sequence set forth in SEQ ID NO:40, wherein the amino acid sequence lacks at least one of the following polypeptide segments:
A polynucleotide fragment that encodes the amino acid sequence set forth in SEQ ID NO:40, wherein the amino acid sequence lacks at least one of the polypeptide segments encoded by the following nucleotide sequences:
A polynucleotide fragment that encodes one or more of the following polypeptide segments:
An isolated polynucleotide comprising one or more of the following nucleotide sequences:
Dependencies are inferred from the claim text.