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US 5,849,572 AGranted
HSV-1 vector containing a lat promoter
AssigneeThe Regents of the University of Michigan
InventorsJoseph C. Glorioso, David J. Fink
Life of this patent
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Abstract
A gene transfer vector for transferring genetic material to a host tissue and expressing a gene product therefrom includes a virus capable of establishing extra chromosomal viral latency in the host tissue. The strain includes at least one foreign gene recombined into the virus which is foreign to the viral genome and a promoter for initiating and driving transcription of the foreign gene during latency of the virus in the host tissue.
Claims7
A herpes simplex virus type 1 vector, capable of establishing latency, comprising
- (a) a latency active transcript promoter encoded by SEQ ID NO:1;
- and
- (b) a heterologous DNA sequence of interest operably linked to said promoter inserted within the genome of said HSV-1.
Dependencies are inferred from the claim text.