Assessment of bone cell activity
AssigneeMillenium Biologix, Inc.
InventorJohn E. Davies
Life of this patent
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Abstract
A calcium phosphate based thin film on which bone cells may be cultured to permit evaluation of bone cell functional properties comprises calcium phosphate entities which provide for varying degrees of resorption of the calcium phosphate entities in evaluating the functional properties. The film is sufficiently thin that resorption of the entities can be detected. Such film, as applied to a support, is a very useful analytical component for evaluating such bone cell functional characteristics. An analytical device, which may be used in an analytical kit, can be provided having a plurality of wells with the devices located at the bottom thereof. A process is provided for making the film and especially the film which has a combination of calcium hydroxyapatite with tricalcium phosphate.
Claims15
A culture substrate for culturing bone cells in vitro to permit evaluation of bone cell functional properties comprising:
- a calcium phosphate based thin film provided on a support substrate wherein said thin film comprises calcium phosphate entities which provide for varying degrees of resorption of said calcium phosphate entities in evaluating said functional properties, said film being sufficiently thin that the degree of resorption of said entities can be determined by the detection of a physical disappearance of calcium phosphate entities.
Dependencies are inferred from the claim text.