Polypeptides from Kaposi's sarcoma-associated herpesvirus, DNA encoding same and uses thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorsYuan Chang, Roy A. Bohenzky, James J. Russo, Isidore S. Edelman, Patrick S. Moore
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Abstract
This invention provides an isolated nucleic acid molecule which encodes Kaposi's Sarcoma-Associated Herpesvirus (KSHV) polypeptides. This invention provides an isolated polypeptide molecule of KSHV. This invention provides an antibody specific to the polypeptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a vaccine for Kaposi's Sarcoma (KS). This invention provides methods of vaccination, prophylaxis, diagnosis and treatment of a subject with KS and of detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.
Claims12
An isolated nucleic acid consisting of the nucleotide sequence encoding Kaposi's sarcoma-associated herpesvirus dihydrofolate reductase having an amino acid sequence as set forth in SEQ ID NO:1.
Dependencies are inferred from the claim text.