Thiodepsipeptide isolated from a marine actinomycete
AssigneePharma Mar, S.A.
InventorsJulia Perez Baz, Francisco Romero Millan, Teresa Garcia De Quesada, Dolores Garcia Gravalos
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Abstract
The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.
Claims3
A process for producing the compound PM-93135, which has the following structure:
- ##STR2## said process comprising cultivating a strain of a microorganism capable of producing the compound PM-93135 in an aqueous nutrient medium with assimilable sources of carbon and nitrogen, under controlled submerged aerobic conditions;
- wherein the PM-93135 producing microorganism is the substantially pure culture strain L-13-ACM2-092, available under accession No. CECT-3326, from the Coleccion Espanola de Cultivos Tipo at the University of Valencia, Spain.
The substantially pure culture strain L-13-ACM2-092 as isolated from marine soft coral, which belongs to the family Micromonosporaceae, and has been taxonomically classified as a Micromonospora sp.
Dependencies are inferred from the claim text.