Compositions and treatments for pneumonia in animals
AssigneeUniversity of Saskatchewan
InventorAndrew A. Potter
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Abstract
New proteins and subunit antigens from P. haemolytica for use in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The subunit antigens include immunogenic amino acid sequences of P. haemolytica fimbrial protein, P. haemolytica plasmin receptor protein, and P. haemolytica 50K outer membrane protein and P. haemolytica leukotoxin. The antigens can be used in a vaccine composition, either alone or in combination. Also disclosed are methods of vaccination as well as methods of making the subunit antigens employed in the vaccines.
Claims25
An isolated nucleic acid molecule comprising a nucleotide sequence that encodes an immunogenic Pasteurella haemolytica leukotoxin polypeptide, wherein said leukotoxin polypeptide has a truncation selected from the group consisting of an N-terminal truncation, a C-terminal truncation, and an N-terminal and C-terminal truncation of the native full length sequence and further wherein said leukotoxin polypeptide comprises the amino acid sequence encoded by the leukotoxin gene present in plasmid pAA342 (ATCC Accession no. 98265), or a nucleic acid molecule that hybridizes thereto under stringent conditions.
Plasmid pAA352 (ATCC Accession no. 68283).
Plasmid pAA342 (ATCC Accession no. 98265).
Plasmid pAA101 (ATCC Accession no. 67883).
Dependencies are inferred from the claim text.