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US 5,849,507 AGranted
Methods to diagnose thrombosis by measuring activation peptide
AssigneeThe Regents of the University of California
InventorShaun R. Coughlin
Life of this patent
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Abstract
Methods for diagnosing thrombosis are disclosed. The methods comprise contacting a biological fluid of a subject with an antibody which binds specifically to the peptide liberated when thrombin receptors are activated.
Claims10
A method for diagnosis of thrombosis in a mammalian subject, which method comprises:
- contacting a sample of the biological fluid of said subject with an antibody, or antibody fragment, which antibody or fragment specifically binds the cleaved activation peptide of the thrombin receptor under conditions wherein said antibody or fragment forms a complex with any said peptide present in said fluid;
- measuring the presence, absence or amount of any complex thus formed;
- wherein the presence, absence or amount of said complex is diagnostic for thrombosis.
Dependencies are inferred from the claim text.