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US 5,849,330 AGranted
Controlled release pharmaceutical
AssigneeOrion-yhtyma Oy
InventorsMartti Lauri Antero Marvola, Taina Sirkia
Life of this patent
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Abstract
The invention relates to long-acting pharmaceutical compositions from which the release of the active compound increases exponentially, and to a process for their preparation. The composition, preferably a tablet, comprises a rapid releasing core and a slow-releasing coat surrounding that core.
Claims12
Oral long-acting composition able to release an active compound continuously in the absence of bursts consisting essentially of:
- (a) a core which contains an active compound in rapid release form, and
- (b) a coating surrounding the core, the coating containing an active compound and a release controlling polymer in a uniform mixture, wherein said coating is prepared by mixing the polymer and the active compound together and pressing the resulting homogeneous mixture around the core, and wherein said polymer consisting essentially of a hydrophilic gel forming polymer is selected from the group consisting of hydroxypropylmethylcellulose, hydroxypropylcellulose, methyl cellulose, sodium carboxymethylcellulose and sodium alginate, and wherein 55 to 99% of the total active compound is in the core and 30-70% of the total composition weight is polymer.
Dependencies are inferred from the claim text.