Use of human transferrin in controlling insulin levels
AssigneeCornell Research Foundation, Inc.
InventorsLuis A. Vargas, Carlos H. Faerman, P. Andrew Karplus
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Abstract
The present invention relates to the use of transferrin in controlling insulin levels. Transferrin can disrupt insulin:receptor interactions in mammalian cells, may be used in mammals to treat hypoglycemia, may also be used to inhibit production of insulin by mammalian cells, and can decrease the serum insulin levels in a mammal. The invention further provides methods for identifying compounds which modulate the effect of transferrin on insulin signal transduction. Pharmaceutical compositions containing transferrin are also disclosed.
Claims6
A method of antagonizing transferrin inhibition of blood glucose metabolism regulated by insulin in a mammal comprising:
- administering to the mammal an antibody which can bind to transferrin under conditions suitable to modulate blood glucose levels.
Dependencies are inferred from the claim text.