Opthalmic non-irritating iodine medicament
AssigneeSymbollon Corporation
InventorJack H. Kessler
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Abstract
The present invention relates to an enzymatically generated iodine microbicide for the inactivation of pathogenic organisms that are contaminants in or on sensitive biological materials such as the human eye. The biocidal agent from the enzymatic reaction is free molecular iodine which is generated at a minimum level of 5 ppm and comprises at least 25% of the total iodine species present on a molar basis.
Claims4
An opthalmic non-irritating iodine anti-infective medicament liquid for treating the eye comprising an iodide-oxidizing peroxidase selected from the group consisting of horseradish peroxidase, lactoperoxidase, myleroperoxidase and soybean-peroxidase, a source of hydrogen peroxide and an iodide source in an admixture with water having a molar ratio of hydrogen peroxide to iodide of between about 0.5 and 4.0 and a maximum concentration of hydrogen peroxide of 0.015% such that free molecular iodine is the principle iodine species generated in the admixture with said admixture having a maximum concentration of hydrogen peroxide of 0.015% such that free molecular iodine is the principle iodine species generated in the admixture and represents a minimum of at least 25% of the total concentration of iodine species on a molar basis with said admixture having a maximum concentration of thiosulfate titratable iodine of 650 ppm and wherein said medicament further comprises a buffer agent to maintain the pH thereof at between pH 4.5 and pH 7.1.
Dependencies are inferred from the claim text.