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US 5,849,287 AGranted
Gene therapy using stromal cells
AssigneesStromagene Corporation, Gene Therapy Sciences, Inc.
InventorsJoel S. Greenberger, Peter H. Levine
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Abstract
A method of causing production and secretion into the bloodsream of a human patient of a biologically active enzyme for which the human patient suffers a deficiency; the method involves introducing into the human patient donor bone marrow stromal cells which have been transfected with a gene encoding the enzyme, so that the introduced cells can adhere to a bone cavity surface of the patient and produce and secrete the active enzyme.
Claims11
A method of delivering a biologically active, mammalian protein into the bloodstream of a mammal, said method comprising:
- (a) obtaining bone marrow stromal cells;
- (b) transfecting said stromal cells with a gene that encodes said protein;
- and
- (c) introducing said transfected stromal cells into the mammal, wherein said cells produce and secrete said biologically active, mammalian protein into the bloodstream of the mammal.
1 more element
Dependencies are inferred from the claim text.